Clinical relevance of endoscopic treatment for superficial pharyngeal cancer feasibility of techniques corresponding to each location and long term outcomes toshiro iizuka md phd et al histopathologic features and fragmentation of polyps with cold snare defect protrusions tatsuya ishii md et al prospective development and validation of a volumetric laser endomicroscopy computer . Background opioid use in pregnancy has escalated dramatically in recent years paralleling the epidemic observed in the general population in 2012 us health care providers wrote more than 259 million prescriptions for opioids twice as many as in 1998 1rates of admission to substance use disorder treatment programs for misuse of prescription opioids more than quadrupled between 2002 and . In the previous article in this series our hypothetical nurse rebecca r with the help of one of her hospitals expert evidence based practice ebp mentors carlos a learned step 1 of the ebp process how to formulate a clinical question the impetus behind her desire to develop her question as you may recall in our case scenario was that rebeccas nurse manager asked her to search . Diagnostic accuracy studies are like other clinical studies at risk of bias due to shortcomings in design and conduct and the results of a diagnostic accuracy study may not apply to other patient groups and settings readers of study reports need to be informed about study design and conduct in sufficient detail to judge the trustworthiness and applicability of the study findings the
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