This book reviews macrocycles in drug discovery both those of natural origin and semi synthetic derivatives of natural products and those designed and synthesized based on principles of medicinal chemistry the medicinal chemistry of macrocyclic natural products is interesting in itself but lessons learned from these compounds in terms of the . Macrocycles in drug discovery rsc drug discovery series amazoncouk levin levin j books. Macrocycles in drug discovery volume 40 of rsc drug discovery series issn 2041 3203 editor jeremy i levin edition illustrated publisher royal society of chemistry 2015 isbn 1849737010. There is a growing body of evidence that macrocycles provide a viable and valuable area of structural space for drug discovery macrocycles are well precedented in nature and many of these . Macrocycles in drug discovery have been defined as a ring system consisting of 12 or more atoms opinions differ on the definition of macrocycles based on ring size but this option usefully captures the qualitative differences in behavior between large macrocyclic rings 12 atoms and medium rings 8 11 atoms
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